Cities with Lowest Unemployment in Missouri

Cities ranked by lowest civilian unemployment rate. 50 cities ranked from official U.S. government data.

What this Missouri ranking shows

According to the U.S. Census Bureau's American Community Survey (ACS) 5-year estimates, the CDC PLACES population-level health analysis, and the CMS Hospital Compare quality data, Areazine ranks U.S. cities across more than 19,000 incorporated places, census-designated places, and consolidated city-county governments. State-level city rankings combine these federal datasets to produce intra-state comparisons across demographics, economics, health outcomes, and hospital quality.

Cape Girardeau leads 50 Missouri cities at 2.3%, while Spanish Lake sits at the bottom with 4.3% — a total spread of 2% on unemployment rate. The top 5 occupy 30% of that range, indicating a moderate distribution with meaningful steps between rungs.

The median Missouri city in this list sits at 3.8%, 1.5% behind Cape Girardeau. See our methodology for ranking construction, data vintage, refresh cadence, and the federal upstream tables we join, and triangulate via the 8 other Missouri rankings below — cities that lead on multiple lenses are the most robust signals.

Top 5 — Lowest Unemployment

Top 5 Missouri cities ranked by unemployment rate
Rank City unemployment rate Population
#1 Cape Girardeau 2.3% 39K
#2 Jackson 2.3% 15K
#3 Maryville 2.4% 12K
#4 O'Fallon 2.9% 85K
#5 Saint Charles 2.9% 66K

Lowest Unemployment 50

More Missouri Rankings 8

Reading this Missouri ranking responsibly

Single-metric rankings are useful precisely because they are honest about what they measure. A "highest income" ranking does not tell you that the top-ranked city is the best place to live in Missouri; it tells you that, among cities of population ten thousand and above in Missouri that have a published median household income field in the most recent American Community Survey five-year estimates, this city has the highest such value. That precise definition matters, because composite "best places" lists from real-estate marketing sites and lifestyle magazines often combine income with subjective weights on schools, walkability, and amenities, producing a score whose components are not disclosed and whose ordering is not reproducible. Areazine's editorial commitment is to keep the underlying field, source, and vintage visible so the reader can audit any rank in this list against the canonical federal record.

Cross-checking against other rankings is a useful sanity test. A city that appears in the top ten on three or more different rankings — for example, highest income, most educated, and lowest poverty — is showing a robust signal across multiple independent dimensions. A city that appears in the top ten on only one ranking and middling on the others is showing a narrower signal, often driven by a single statistical artifact (a small population pulling the per-capita measure, a recent acquisition spike inflating median home value, an outlier survey year). The other nine Missouri rankings linked above provide that cross-check at zero extra effort.

Data Sources

Population and economic data from the Census Bureau American Community Survey (2022 5-year estimates). Health data from the CDC PLACES (2023). Ranking computations use U.S. Census Bureau reference geographies. Crime statistics, where referenced, originate from the FBI Uniform Crime Reporting program (also accessible via the Crime Data Explorer).