Shortage Update for Methotrexate Sodium Injection
Areazine synthesizes this FDA drug-shortage notice directly from FDA's official public data feed. See our methodology for full source attribution and refresh cadence.
Methotrexate Sodium Injection is currently experiencing limited availability for some presentations, as per the FDA Drug Shortage Database, affecting patients in rheumatology and oncology.
What this FDA drug-shortage notice tells you, and what most readers miss
This notice was issued by FDA on April 7, 2026 and geographically references United States. Its severity classification of "medium" signals how the issuing agency weighs the risk of harm if no action is taken - "critical" and "high" tier alerts typically carry direct consumer actions, while "medium" and "low" tend toward informational guidance or monitoring advisories. The category it belongs to - Drug Shortages - determines the regulatory framework behind it, which shapes what mitigations (alternative therapies, allocation timelines, manufacturer guidance) are available and which agency holds oversight.
Most readers skim a notice like this, check whether they are personally affected, and move on. The more useful lens is to read it as a data point about the issuing system: how quickly FDA detected the hazard, how precise the geographic or product-identifier scope is, and whether similar notices have clustered in the same category or region in the last 90 days. Cluster patterns frequently precede a broader regulatory action, a single localized FDA drug-shortage notice is isolated; three of them within a quarter often indicate a supply-chain, infrastructure, or seasonal driver that will keep producing notices until something structural changes.
For decision-making, Areazine pairs each alert with the original agency URL, the full agency name, and a timestamp so you can verify the notice against the primary source before acting on it. Tags on this item (drug-shortage, fda, medication, Methotrexate Sodium Injection) map to related alerts in the same area of risk - browsing them together gives a clearer picture than any single notice alone, because the shape of an ongoing issue only becomes visible across multiple sequential alerts.
What's in Shortage
The drug in shortage is Methotrexate Sodium Injection, with brand name METHOTREXATE. It is available in injection dosage form and falls under the therapeutic categories of Rheumatology and Oncology. The shortage status is current, with the initial posting date of 03/13/2023 and last updated on 03/27/2026.
Which Manufacturers Are Affected
- Hospira, Inc., a Pfizer Company: Available for presentations including Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-25), 50 mg/2 mL (25 mg/mL) (NDC 61703-350-38), 50 mg/2 mL (25 mg/mL) (NDC 61703-350-10), 1 g/40 mL (25 mg/mL) (NDC 61703-408-41), and 1 g/40 mL (25 mg/mL) (NDC 61703-124-40). Contact info: 844-646-4398.
- Fresenius Kabi USA, LLC: Available for presentations including Methotrexate Sodium, Injection, 25 mg/1 mL (NDC 63323-123-10) and Methotrexate Preservative Free, Injection, 1 g (NDC 63323-122-50). Related info: Check wholesaler for inventory. Contact info: 888-386-1300.
- Teva Pharmaceuticals USA, Inc.: Available for Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3675-01); Limited Availability for Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3671-01), with estimated recovery TBD. Contact info: 800-545-8800.
Why There's a Shortage
No specific reason for the shortage was provided in the source data.
What Patients Should Do
Patients who rely on Methotrexate Sodium Injection should speak with their pharmacist or healthcare provider to check availability and discuss options. It may be helpful to contact the manufacturer directly for more information. Remember, patients should always consult their healthcare provider before making any changes to their medication routine, as this article does not provide medical advice.
Source
This information is sourced from the FDA Drug Shortage Database.
Original source: FDA Official Notice ↗
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