Methylprednisolone Acetate Injection Shortage: Current Availability and Manufacturer Updates

What’s in Shortage

Methylprednisolone Acetate Injection, a medication primarily used within the therapeutic category of rheumatology, is currently listed as being in shortage. The shortage affects multiple strengths, specifically the 40 mg/1 mL and 80 mg/1 mL presentations. This shortage status was first posted on December 15, 2021, and was most recently updated on February 9, 2026.

Which Manufacturers Are Affected

Several manufacturers are currently experiencing supply issues, while others maintain limited or full inventory:

• Amneal Pharmaceuticals (866-525-7270):
  • 80 mg/1 mL (NDC 70121-1574-5): Available; 2 to 4 weeks of inventory based on demand. Next supply expected week of February 9, 2026.
  • 80 mg/1 mL (NDC 70121-1574-1): Available; 4 to 8 weeks of inventory. Next supply expected week of March 16, 2026.
  • 40 mg/1 mL (NDC 70121-1573-5): Available, but currently under backorder due to demand. Next supply expected week of February 9, 2026.
  • 40 mg/1 mL (NDC 70121-1573-1): Limited Availability; 4 to 6 weeks of inventory. Next supply expected week of February 9, 2026.
• Sagent Pharmaceuticals (866-625-1618):
  • 40 mg/1 mL (NDC 25021-820-10) and 80 mg/1 mL (NDC 25021-821-05): Available.
  • 40 mg/1 mL (NDC 25021-820-05): Limited Availability; estimated availability May 2026.
• Eugia US LLC (888-238-7880):
  • 40 mg/1 mL and 80 mg/1 mL: Unavailable. Currently on backorder with a recovery date to be determined. Patients and providers are advised to check wholesalers for inventory.
• Par Health, USA LLC (800-828-9393):
  • 80 mg/1 mL (NDC 42023-240-01): Unavailable.

Why There’s a Shortage

The source data does not provide a specific underlying cause for the shortage, though some manufacturers note that current inventory levels are being impacted by high demand.

What Patients Should Do

If you rely on Methylprednisolone Acetate Injection for your treatment, please consider the following steps:

• Consult Your Healthcare Provider: Speak with your doctor regarding your treatment plan and potential alternatives if your specific dosage is unavailable.
• Speak with Your Pharmacist: Pharmacists may have information on local stock or may be able to source the medication from different wholesalers.
• Contact Manufacturers: You may use the contact information provided above to inquire about the most recent availability updates for specific NDCs.

Disclaimer: Patients should always consult with their healthcare provider or pharmacist for medical advice and before making any changes to their medication regimen.

Source

Information provided by the FDA Drug Shortage Database.